Binding of the Origin Recognition Jewelry Complex (ORC) to origins of replication marks the first step in the initiation of replication of the genome in all eukaryotic cells.Here, we report the structure of the active form of human ORC determined by X-ray crystallography and cryo-electron microscopy.The complex is composed of an ORC1/4/5 motor modu
A variety of emerging technologies, such as visible light communication systems, require narrow linewidths and easy-to-integrate light sources.Such a requirement could be potentially fulfilled with the distributed Bragg reflector (DBR) lasers, which are also promising for the monolithical integration with other optical components.The InGaN/GaN-base
Study region: The Guadalquivir Basin in Spain as a representative Mediterranean basin.Study focus: The aim of this study is to assess the adaptive capacity of Mediterranean basins to long periods of severe drought.To do so, a hydro-economic model has been developed that includes a spatial representation of the major economic uses of water and enabl
In the Republic of Macedonia, the legislator has tried to solve the problem of late payment in commercial transactions by enacting the Financial Discipline Act.The justifications for Tridonic PC Ballasts enacting this Act were the illiquidity of the business sector and the implementation of the EU Directive on combating late payment in commercial t